Lucknow/New Delhi: The presence of the NDM-1 gene, which alters bacteria and makes them resistant to antibiotics, was detected in India in a study which concluded last year, a study that’s, ironically, being trashed by the Government as “shocking and unscientific.”
What all of them seemingly glossed over is the fact that six Indian institutes, including the Department of Microbiology at Banaras Hindu University's Institute of Medical Sciences and the Microbiology Department at the University of Madras in Chennai, participated in the study in collaboration with Cardiff University, UK, and Stockholm's prestigious Karolinska University Hospital.
"It is the most unscientific article and I am shocked that Lancet has published it. There is a conflict of interest and there is clearly no science behind it," K Sujatha Rao, Health Secretary told The Indian Express.
Late in 2008, the Antibiotic Resistance Monitoring and Reference Lab of the UK-based Health Protection Agency (HPA) sounded an alarm across the world about the New Delhi metallo-ß-lactamase 1 (NDM-1) gene.
"We found cases of drug-resistant patients in Sir Sunderlal Hospital and we started a study on our own when we found the information about this gene on the net," said Dr M R Sen, professor at the Department of Microbiology of BHU's Institute of Medical Sciences, one of the participating institutions.
At that time, Cardiff University, which had been in touch with HPA, was also working on the gene along with some other Indian institutions. "The British researchers found that the patients had a recent travel history to India and Pakistan. The study was conducted almost simultaneously at various other centres in India," said Dr Sen.
Sen said the existence of this gene is common in bacteria like E. Coli (which causes urinary tract infections) and K. Peumoniae (which causes pneumonia). "Though the detection of E. Coli and K. Peumoniae is easy, and even their resistance against common drugs can be tested in a routine way, the trick is to test whether the bacteria is resistant to all antibiotics like carbapenems which is one of the latest antibiotics effective on most of the bacteria", said Sen.
This drug-resistant bacteria first spreads in hospitals and strikes at the community level only at a very later stage, Sen said. He added that if detected early in a patient, the bacteria can be tackled medically. But once the infection spreads, it is difficult to contain it and may cause septicemia in patients, he said.
"This (the conclusion) is not supported by any scientific data. This occurs in nature and in the intestines of animals and humans universally. Similar strains are found in the US and UK," said Ichhpujani.
Some experts said that such organisms may be circulating more commonly in the world due to international travel and to link this with the safety of surgery in hospitals in India is wrong.
Adding that the study should be an eye opener as regulations are needed on the use of antibiotics anyways, he said, "There should be an independent policy by each policy on the use of antibiotics."
The Government said the study was funded by the European Union and a pharma company, Wyeth, that produces antibiotics. Said Dr Misra: "The study does no good to the pharma companies as well and Lancet is very strict about these issues. They definitely take in account the funding. I know how professional they are. It is unfair to say there is a conflict of interest."
Source: The Indian Express